Some of you are aware that Vista SP1 is coming.
You may not know that it is breaking some programs [Zone Alarm Security Suite 7.1, Trend Micro Internet Security 2008, and BitDefender 10] and has severe problems with drivers. SP1 has been held back until mid-March with a second version of SP1 coming out later this year that will fix driver problems.
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Note: Original article found at InformationWeek, Windows Vista SP1 Blocks Antivirus Programs.